A novel role of HuR in -Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis

J Cell Mol Med. 2019 May;23(5):3767-3771. doi: 10.1111/jcmm.14249. Epub 2019 Feb 22.

Authors

Wenxuan Jian¹, Shuhuan Fang¹, Tongkai Chen¹, Jiansong Fang¹, Yousheng Mo¹, Dongli Li¹, Sha Xiong¹, Wei Liu¹, Lei Song¹, Jiangang Shen^{1

2}, Yong Xia³, Qi Wang¹, Honghai Hong^{3

4}

Affiliations

¹ DME Center, Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
² School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
³ Department of Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
⁴ Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ADAM10 Protein / genetics
ADAM10 Protein / metabolism
Amyloid Precursor Protein Secretases / genetics
Amyloid Precursor Protein Secretases / metabolism
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism
Animals
Apoptosis / drug effects*
Apoptosis / genetics
Catechin / analogs & derivatives*
Catechin / pharmacology
ELAV-Like Protein 1 / genetics
ELAV-Like Protein 1 / metabolism*
Gene Expression Regulation, Neoplastic / drug effects
Hep G2 Cells
Humans
MAP Kinase Signaling System / drug effects
MAP Kinase Signaling System / genetics
Membrane Proteins / genetics
Membrane Proteins / metabolism
Neoplasms / genetics
Neoplasms / metabolism*
Neoplasms / pathology
PC12 Cells
Proto-Oncogene Proteins c-bcl-2 / metabolism
Rats
bcl-2-Associated X Protein / metabolism

Substances

Amyloid beta-Protein Precursor
ELAV-Like Protein 1
Membrane Proteins
Proto-Oncogene Proteins c-bcl-2
bcl-2-Associated X Protein
Catechin
epigallocatechin gallate
Amyloid Precursor Protein Secretases
ADAM10 Protein
ADAM10 protein, human