Chemistry Helps to Bump Off-Target Edits Away

Thorsten Stafforst

doi:10.1016/j.chembiol.2019.02.005

Chemistry Helps to Bump Off-Target Edits Away

Cell Chem Biol. 2019 Feb 21;26(2):151-152. doi: 10.1016/j.chembiol.2019.02.005.

Author

Thorsten Stafforst¹

Affiliation

¹ Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany. Electronic address: [email protected].

PMID: 30794785
DOI: 10.1016/j.chembiol.2019.02.005

Abstract

Side-directed RNA editing is an emerging tool to manipulate genetic information. Unfortunately, most approaches suffer from off-target editing. In this issue of Cell Chemical Biology, Monteleone et al. (2019) present a clever strategy that improves specificity by combining a mutant editase with a compensating chemical modification in the guiding RNA.

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MeSH terms

RNA Editing*