Abstract
In this report we describe the use of an IgA-depleted preparation of intravenous gamma-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous gamma-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Agammaglobulinemia / immunology
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Agammaglobulinemia / therapy*
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Antibodies, Anti-Idiotypic / analysis
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Antibodies, Anti-Idiotypic / biosynthesis*
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Antigen-Antibody Complex / metabolism
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Complement Activation
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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IgA Deficiency*
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Immunoglobulin A / immunology
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Immunoglobulin A, Secretory
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Immunoglobulin G / therapeutic use*
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Immunoglobulins, Intravenous
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Middle Aged
Substances
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Antibodies, Anti-Idiotypic
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Antigen-Antibody Complex
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Immunoglobulin A
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Immunoglobulin A, Secretory
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Immunoglobulin G
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Immunoglobulins, Intravenous