Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Eline Haspeslagh; Manon Vanheerswynghels; Kim Deswarte; Justine Van Moorleghem; Alain Jacquet; Bart N Lambrecht; Hamida Hammad

doi:10.1016/j.jaci.2019.02.007

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

J Allergy Clin Immunol. 2019 Jun;143(6):2307-2311.e5. doi: 10.1016/j.jaci.2019.02.007. Epub 2019 Feb 20.

Authors

Eline Haspeslagh¹, Manon Vanheerswynghels¹, Kim Deswarte¹, Justine Van Moorleghem¹, Alain Jacquet², Bart N Lambrecht³, Hamida Hammad⁴

Affiliations

¹ Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
² Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
³ Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands.
⁴ Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. Electronic address: [email protected].

Abstract

This mouse study demonstrates that repetitive inhalation of a single major house dust mite (HDM) allergen prevents HDM-induced allergic asthma development through suppressing the function of lung dendritic cells, thus providing an alternative to classical allergen-specific immunotherapy.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / immunology*
Animals
Antigens, Dermatophagoides / immunology*
Arthropod Proteins / immunology*
Asthma / immunology
Asthma / therapy*
Desensitization, Immunologic*
Disease Models, Animal
Female
Granulocyte-Macrophage Colony-Stimulating Factor / immunology*
Lung / immunology*
Mice, Inbred C57BL

Substances

Allergens
Antigens, Dermatophagoides
Arthropod Proteins
Dermatophagoides pteronyssinus antigen p 2
Granulocyte-Macrophage Colony-Stimulating Factor

Grants and funding

789384/ERC_/European Research Council/International