Making New Connections-Chromosome Conformation Capture for Identification of Disease-Associated Target Genes

Matthew T Patrick; Lam C Tsoi; Johann E Gudjonsson

doi:10.1016/j.jid.2018.11.026

Making New Connections-Chromosome Conformation Capture for Identification of Disease-Associated Target Genes

J Invest Dermatol. 2019 Mar;139(3):514-517. doi: 10.1016/j.jid.2018.11.026.

Authors

Matthew T Patrick¹, Lam C Tsoi², Johann E Gudjonsson³

Affiliations

¹ Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
² Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
³ Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: [email protected].

PMID: 30797317
DOI: 10.1016/j.jid.2018.11.026

Abstract

Most susceptibility loci for complex dermatologic diseases fall within non-coding regions, making assignment of function difficult. Chromosome conformation capture addresses this problem by using the spatial organization of chromatin to identify the genes these loci interact with, often across long distances. Furthermore, as gene regulation is tissue-/cell-dependent, studying relevant cell populations is critical to reveal the molecular mechanisms involved.

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MeSH terms

Chromatin
Chromosomes
Connectome*
Gene Expression Regulation

Substances

Chromatin