Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade
JCO Precis Oncol
.
2018:2018:PO.18.00190.
doi: 10.1200/PO.18.00190.
Epub 2018 Nov 27.
Authors
Ian F Dunn
#
1
,
Ziming Du
#
2
3
,
Mehdi Touat
4
5
,
Michael B Sisti
6
,
Patrick Y Wen
7
8
,
Renato Umeton
9
,
Adrian M Dubuc
2
,
Matthew Ducar
9
10
,
Peter D Canoll
11
,
Eric Severson
12
,
Julia A Elvin
13
,
Shakti H Ramkissoon
12
14
,
Jia-Ren Lin
3
15
,
Lais Cabrera
8
,
Brenda Acevedo
8
,
Peter K Sorger
3
15
16
,
Keith L Ligon
2
4
5
,
Sandro Santagata
#
2
3
5
15
,
David A Reardon
#
4
8
Affiliations
1
Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA.
2
Department of Pathology, Brigham and Women's Hospital, Boston, MA.
3
Ludwig Center at Harvard Medical School, Boston, MA.
4
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
5
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA.
6
Department of Neurosurgery, Columbia University Medical Center, New York City, NY.
7
Department of Neurology, Brigham and Women's Hospital, Boston, MA.
8
Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA.
9
Department of Informatics, Dana-Farber Cancer Institute, Boston, MA.
10
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA.
11
Department of Pathology and Cell Biology, Columbia University Medical Center, New York City, NY.
12
Foundation Medicine, Inc., Morrisville, NC.
13
Foundation Medicine, Inc., Cambridge, MA.
14
Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC.
15
Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA.
16
Department of Systems Biology, Harvard Medical School, Boston, MA.
#
Contributed equally.
PMID:
30801050
PMCID:
PMC6383717
DOI:
10.1200/PO.18.00190
No abstract available
Grants and funding
U54 CA225088/CA/NCI NIH HHS/United States