Abstract
Thirteen sesquiterpenes including eight new ones, magnodelavins A-H (1-8), were obtained from the 95 % ethanolic extract of the leaves of Magnolia delavayi Franch. The structures of the new compounds were determined by exhaustive 1 H-, 13 C-, 2D-NMR, UV, IR, and HR-ESI-MS data, as well as X-ray crystallographic analysis. Compounds 9 and 10 showed potent cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, and SW480 human cancer cell lines in vitro using MTS assay.
Keywords:
Magnolia delavayi; cytotoxicity; phytochemistry; sesquiterpene; structure elucidation.
© 2019 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Magnetic Resonance Spectroscopy
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Magnolia / chemistry*
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Magnolia / metabolism
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Molecular Conformation
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Plant Leaves / chemistry
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Plant Leaves / metabolism
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes