Abstract
Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation.
Dasatinib could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD19 / immunology
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cytokines / drug effects
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Dasatinib / pharmacology*
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Heterografts
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Humans
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Lymphocyte Activation / drug effects
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Mice
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Protein Kinase Inhibitors / pharmacology
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Receptors, Chimeric Antigen*
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
Substances
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Antigens, CD19
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CD19 molecule, human
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Cytokines
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Protein Kinase Inhibitors
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Receptors, Chimeric Antigen
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Dasatinib