Abstract
An 'on-demand' drug release and ROS-responsive nanoparticle was prepared by chemically conjugating hydrophobic α-tocopheryl succinate to hydrophilic poly(ethylene glycol) via a thioketal linker. This nanoparticle encapsulated with doxorubicin and α-tocopheryl succinate exhibited remarkable efficiency in reversing multidrug resistance both in vitro and in vivo.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / metabolism
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Antibiotics, Antineoplastic / pharmacology*
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Antibiotics, Antineoplastic / therapeutic use
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Cell Survival / drug effects
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Doxorubicin / metabolism
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Doxorubicin / pharmacology*
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Doxorubicin / therapeutic use
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Drug Carriers / chemistry*
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Drug Liberation
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Drug Resistance, Neoplasm / drug effects*
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Humans
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Hydrophobic and Hydrophilic Interactions
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MCF-7 Cells
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Mice
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Micelles
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Nanoparticles / chemistry*
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Neoplasms / drug therapy
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Neoplasms / pathology
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Polyethylene Glycols / chemistry
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Reactive Oxygen Species / metabolism*
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Transplantation, Heterologous
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alpha-Tocopherol / chemistry
Substances
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Antibiotics, Antineoplastic
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Drug Carriers
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Micelles
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Reactive Oxygen Species
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Polyethylene Glycols
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Doxorubicin
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alpha-Tocopherol