Purpose: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams.
Methods: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data.
Results and conclusions: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
Keywords: Geant4; Monte Carlo; Proton; RBE; Radiobiological model; Radiotherapy; Survival fraction.
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