Report of the Survey Conducted by RCPAQAP on Current Practice for Paraprotein and Serum Free Light Chain Measurement and Reporting: a Need for Harmonisation

Nilika Wijeratne; Jillian R Tate; Louise Wienholt; Peter Mollee

Report of the Survey Conducted by RCPAQAP on Current Practice for Paraprotein and Serum Free Light Chain Measurement and Reporting: a Need for Harmonisation

Clin Biochem Rev. 2019 Feb;40(1):31-42.

Authors

Nilika Wijeratne^{1

2

3}, Jillian R Tate⁴, Louise Wienholt⁵, Peter Mollee^{6

7}

Affiliations

¹ Dorevitch Pathology, Heidelberg, Vic. 3084, Australia.
² Monash Pathology, Monash Health, Clayton, Vic. 3168, Australia.
³ Department of Medicine, Monash University, Clayton, Vic. 3168, Australia.
⁴ Chemical Pathology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, Qld 4029, Australia.
⁵ The Royal College of Pathologists of Australasia Quality Assurance Programs (RCPAQAP), St Leonards, NSW 2065, Australia.
⁶ Haematology Department, Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia.
⁷ School of Medicine, University of Queensland, Woolloongabba, Qld 4102, Australia.

PMID: 30828118
PMCID: PMC6370284

Abstract

Clinical laboratory testing is vital in the diagnosis, monitoring and prognostication of monoclonal gammopathies. Although the 2012 recommendations for standardised reporting of protein electrophoresis in Australia and New Zealand aimed to harmonise the laboratory practices related to paraprotein testing, the between-laboratory variation still exists. A survey was conducted to assess the between-laboratory variation in certain aspects of laboratory testing related to monoclonal gammopathy.