Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia

Blood Adv. 2019 Mar 12;3(5):761-765. doi: 10.1182/bloodadvances.2018023879.

Heiko Becker^{1

2

3}, Gabriele Greve^{1

2}, Keisuke Kataoka⁴, Jan-Philipp Mallm^{5

6}, Jesús Duque-Afonso^{1

2

7}, Tobias Ma^{1

2}, Christoph Niemöller^{1

2}, Milena Pantic¹, Justus Duyster^{1

2

3}, Michael L Cleary⁷, Julia Schüler⁸, Karsten Rippe^{5

6}, Seishi Ogawa³, Michael Lübbert^{1

2

3}

¹ Department of Medicine I, Medical Center, and.
² Faculty of Medicine, University of Freiburg, Freiburg, Germany.
³ German Cancer Consortium partner site, Freiburg, Germany.
⁴ Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
⁵ Division of Chromatin Networks and.
⁶ Single-cell Open Laboratory, German Cancer Research Center, Heidelberg, Germany.
⁷ Department of Pathology, Stanford University, Stanford, CA; and.
⁸ Charles River Discovery Research Services Germany GmbH, Freiburg, Germany.

Abstract

mRNA decapping gene EDC4 is a novel fusion partner of MLL in AML.
Genes functioning in mRNA decapping may compose a distinct group of MLL fusion partners that links MLL function with mRNA decapping in AML.