Abstract
In this report, we demonstrate that half-curcuminoid could be a better scaffold for PET tracer development. F-CRANAD-101 was designed and found to show significant response to both soluble and insoluble Aβs in the fluorescent spectral tests. PET imaging results indicated that 14 month and 5 month old APP/PS1 AD mice had higher signals in the brain than age-matched wild type mice.
MeSH terms
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Alzheimer Disease / diagnosis
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Alzheimer Disease / diagnostic imaging
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Alzheimer Disease / pathology
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Amyloid beta-Peptides / metabolism*
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Animals
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Brain / pathology
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Curcumin / analogs & derivatives*
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Mice
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Mice, Transgenic
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Microscopy, Fluorescence
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Positron-Emission Tomography*
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Radiopharmaceuticals / chemistry
Substances
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Amyloid beta-Peptides
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Radiopharmaceuticals
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Curcumin