Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Joel W Blanchard; Li-Huei Tsai

doi:10.1016/j.stem.2019.02.003

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Cell Stem Cell. 2019 Mar 7;24(3):347-349. doi: 10.1016/j.stem.2019.02.003.

Authors

Joel W Blanchard¹, Li-Huei Tsai²

Affiliations

¹ Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address: [email protected].

PMID: 30849361
DOI: 10.1016/j.stem.2019.02.003

Abstract

Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.

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MeSH terms

Alzheimer Disease*
Amyloid beta-Peptides
Cholesterol
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Neurons
tau Proteins

Substances

Amyloid beta-Peptides
Hydroxymethylglutaryl-CoA Reductase Inhibitors
tau Proteins
Cholesterol