Liquid Active Zones for Controlling the Phases of Synaptic Transmission

Javier Emperador-Melero; Pascal S Kaeser

doi:10.1016/j.molcel.2019.02.020

Liquid Active Zones for Controlling the Phases of Synaptic Transmission

Mol Cell. 2019 Mar 7;73(5):859-860. doi: 10.1016/j.molcel.2019.02.020.

Authors

Javier Emperador-Melero¹, Pascal S Kaeser²

Affiliations

¹ Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 30849390
DOI: 10.1016/j.molcel.2019.02.020

Abstract

Wu et al. (2019) establish that the active zone proteins RIM and RIM-BP undergo liquid-liquid phase separation to tether Ca²⁺ channels. This important finding sets a new framework to study assembly and function of the presynaptic nerve terminal.

Liquid Active Zones for Controlling the Phases of Synaptic Transmission

Authors

Affiliations

Abstract

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