Updates in spindle cell/pleomorphic lipomas

Benjamin J Van Treeck; Karen J Fritchie

doi:10.1053/j.semdp.2019.02.005

Updates in spindle cell/pleomorphic lipomas

Semin Diagn Pathol. 2019 Mar;36(2):105-111. doi: 10.1053/j.semdp.2019.02.005. Epub 2019 Feb 28.

Authors

Benjamin J Van Treeck¹, Karen J Fritchie²

Affiliations

¹ Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA. Electronic address: [email protected].

PMID: 30850230
DOI: 10.1053/j.semdp.2019.02.005

Abstract

Spindle cell/pleomorphic lipomas are benign lipomatous neoplasms that show loss of RB1 and classically harbor components of mature adipose tissue, bland spindled cells and ropy collagen. This review highlights the clinicopathologic features and morphologic spectrum of spindle cell/pleomorphic lipoma, discusses an updated differential diagnosis, and provides a practical diagnostic strategy for spindle cell/pleomorphic lipomas with atypical clinical presentations.

Keywords: CD34; Pleomorphic lipoma; RB1; Spindle cell lipoma.

Publication types

Review

MeSH terms

Diagnosis, Differential
Humans
Lipoma / diagnosis*
Lipoma / pathology*