Platelet transfusion thresholds in premature neonates (PlaNeT-2 trial)

L J Estcourt

doi:10.1111/tme.12587

Platelet transfusion thresholds in premature neonates (PlaNeT-2 trial)

Transfus Med. 2019 Feb;29(1):20-22. doi: 10.1111/tme.12587.

Author

L J Estcourt^{1

2}

Affiliations

¹ NHS Blood and Transplant, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
² Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

PMID: 30859640
DOI: 10.1111/tme.12587

Abstract

Clinical question: Does transfusing platelets to preterm infants (< 34 weeks) at a higher platelet count threshold count (< 50 x 10⁹ /L) reduce the risk of major bleeding or death compared to only transfusing platelets when the platelet count drops below 25 x 10⁹ /L.

Evidence from trial: Preterm infants with a low platelet count who were transfused platelets at the higher platelet count threshold had a higher risk of dying or having a major bleed than those who were not. The reasons why this occurred are currently unclear.

Keywords: neonate; platelet transfusion; thrombocytopenia.

Publication types

Clinical Trial, Phase II
Multicenter Study

MeSH terms

Female
Hemorrhage / mortality*
Hemorrhage / therapy*
Humans
Infant, Newborn
Infant, Premature*
Male
Platelet Transfusion*
Thrombocytopenia / mortality*
Thrombocytopenia / therapy*