Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Praful R Nair; Denis Wirtz

doi:10.1083/jcb.201902035

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

J Cell Biol. 2019 Apr 1;218(4):1092-1093. doi: 10.1083/jcb.201902035. Epub 2019 Mar 14.

Authors

Praful R Nair¹, Denis Wirtz^{2

3

4

5}

Affiliations

¹ Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD.
² Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD [email protected].
³ Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
⁴ Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁵ Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Abstract

Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing
Cell Movement
Female
Focal Adhesions*
Humans
Phosphoproteins*
Pregnancy
Transcription Factors

Substances

Adaptor Proteins, Signal Transducing
Phosphoproteins
Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding