Abstract
A novel nonapeptide with neurotensin-like immunoreactivity was isolated from pepsin-treated human plasma by dialysis, ion-exchange chromatography and high performance reversed-phase liquid chromatography. The amino acid sequence was determined by automated gas-phase sequence analysis as Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Sequence homology with human serum albumin and with the biologically active peptides neurotensin and angiotensin is demonstrated. The name proposed for this peptide is kinetensin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Angiotensin I / analysis*
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Angiotensins / analysis*
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Animals
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Cattle
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Chickens
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Chromatography, High Pressure Liquid
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Humans
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Microchemistry
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Neurotensin / analysis*
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Oligopeptides / analysis*
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Pepsin A / metabolism*
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Peptide Fragments / analysis
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Peptides
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Serum Albumin / analysis*
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Swine
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Xenopus
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Xenopus Proteins*
Substances
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Angiotensins
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Oligopeptides
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Peptide Fragments
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Peptides
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Serum Albumin
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Xenopus Proteins
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neuromedin N
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kinetensin
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Neurotensin
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xenopsin
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neurotensin-related hexapeptide
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Angiotensin I
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Pepsin A