Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture

Circulation. 2019 Mar 19;139(12):1554-1556. doi: 10.1161/CIRCULATIONAHA.118.038383.

Zhiyuan Zhang^{1

2}, Yongxin Mu^{1

2}, Jianlin Zhang¹, Yangzhao Zhou¹, Paola Cattaneo^{3

4}, Jennifer Veevers¹, Angela K Peter^{1

5}, Ana Maria Manso^{1

6}, Kirk U Knowlton^{1

7}, Xinmin Zhou², Sylvia M Evans¹, Robert S Ross^{1

6}, Ju Chen¹

¹ Department of Medicine-Cardiology, University of California San Diego, La Jolla (Z.Z., Y.M., J.Z., Y.Z., J.V., A.K.P., A.M.M., K.U.K., S.M.E., R.S.R., J.C.).
² Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (Z.Z., Y.Z., X.Z.).
³ National Research Council, Institute of Genetics and Biomedical Research, Milan Unit, Italy (P.C.).
⁴ Humanitas Clinical and Research Center, Rozzano (MI), Italy (P.C.).
⁵ Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado, Boulder (A.K.P.).
⁶ Veterans Administration Healthcare, Medicine/Cardiology, San Diego, CA (A.M.M., R.S.R.).
⁷ Intermountain Heart Institute Intermountain Medical Center, Salt Lake City, UT (K.U.K.).

No abstract available

Keywords: aneurysm; basement membrane; extracellular matrix; heart; integrin; myocardium.

Publication types