The fight against multidrug-resistant organisms: The role of ZnO crystalline defects

Mater Sci Eng C Mater Biol Appl. 2019 Jun:99:575-581. doi: 10.1016/j.msec.2019.02.004. Epub 2019 Feb 2.

Abstract

This article reports the excellent antimicrobial response of nanoparticulate ZnO against multidrug-resistant organisms (MDROs). We demonstrate that the enhanced antimicrobial activity against MDROs depends on the crystalline defects of ZnO. Hence, this work provides insights on the ZnO-microorganism interactions, and we pose combined physico-chemical action mechanisms against resistant bacteria.

Keywords: Action mechanisms; Antimicrobial properties; MDROs; Nanoparticles; ZnO.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteria / drug effects
  • Crystallization
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Microbial Sensitivity Tests
  • Nanoparticles / chemistry
  • Nanoparticles / ultrastructure
  • Reactive Oxygen Species / metabolism
  • Zinc Oxide / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Reactive Oxygen Species
  • Zinc Oxide