Dissecting the Toxic Effects of Zika Virus Proteins on Neural Progenitor Cells

Raiane O Ferreira; Patricia P Garcez

doi:10.1016/j.neuron.2019.03.009

Dissecting the Toxic Effects of Zika Virus Proteins on Neural Progenitor Cells

Neuron. 2019 Mar 20;101(6):989-991. doi: 10.1016/j.neuron.2019.03.009.

Authors

Raiane O Ferreira¹, Patricia P Garcez²

Affiliations

¹ Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
² Institute of Biomedical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: [email protected].

PMID: 30897362
DOI: 10.1016/j.neuron.2019.03.009

Abstract

The mechanisms by which Zika virus (ZIKV) disrupts neurogenesis and causes microcephaly are poorly understood. In this issue of Neuron, Li et al. (2019) demonstrate that ZIKV protease NS2B-NS3 heterodimers cleave Septin-2 and lead to cytokinesis defects.

Keywords: Zika virus; brain malformation; congenital Zika syndrome; cytokinesis; microcephaly; neural stem cells; pathogenesis; septin.

Publication types

Comment

MeSH terms

Humans
Microcephaly*
Neural Stem Cells*
Septins
Zika Virus Infection*
Zika Virus*

Substances

Septins