Impact of Antibiotic Therapy in the Microbiological Yield of Healthcare-Associated Ventriculitis and Meningitis

Thomas Rogers; Kevin Sok; Timothy Erickson; Elizabeth Aguilera; Susan H Wootton; Kristy O Murray; Rodrigo Hasbun

doi:10.1093/ofid/ofz050

Impact of Antibiotic Therapy in the Microbiological Yield of Healthcare-Associated Ventriculitis and Meningitis

Open Forum Infect Dis. 2019 Feb 6;6(3):ofz050. doi: 10.1093/ofid/ofz050. eCollection 2019 Mar.

Authors

Thomas Rogers¹, Kevin Sok¹, Timothy Erickson², Elizabeth Aguilera³, Susan H Wootton³, Kristy O Murray², Rodrigo Hasbun¹

Affiliations

¹ Infectious Disease Division, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center in Houston, Houston, Texas.
² Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
³ Infectious Disease Division, Department of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, Texas.

Abstract

The impact of antibiotic therapy on the diagnosis of healthcare-associated ventriculitis and meningitis (HCAVM) is unknown. Antibiotics were administered before obtaining cerebrospinal fluid (CSF) in 217 out of 326 (66%) patients with HCAVM, and they impacted the sensitivity of the cerebrospinal fluid Gram stain and culture (P ≤ .004).

Keywords: CSF culture; antibiotic; healthcare-associated; meningitis; ventriculitis.