Abstract
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / blood*
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Anti-Bacterial Agents / chemistry*
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Cephalosporins / blood*
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Cephalosporins / chemistry*
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Cephalosporins