Cystic fibrosis in the modern therapeutic era: Give the shower a thought!

Déborah Le Pennec; Melisande Baravalle-Einaudi; Christian Dupont; Laurent Vecellio; Jean-Christophe Dubus; GRAM (Aerosols and Cystic Fibrosis Workgroup of the French Cystic Fibrosis Society)

doi:10.1016/j.jcf.2019.03.004

Cystic fibrosis in the modern therapeutic era: Give the shower a thought!

J Cyst Fibros. 2019 Nov;18(6):e56-e57. doi: 10.1016/j.jcf.2019.03.004. Epub 2019 Mar 21.

Authors

Déborah Le Pennec¹, Melisande Baravalle-Einaudi², Christian Dupont³, Laurent Vecellio¹, Jean-Christophe Dubus⁴; GRAM (Aerosols and Cystic Fibrosis Workgroup of the French Cystic Fibrosis Society)

Affiliations

¹ INSERM U1100, Respiratory Diseases Centre, Tours University, Tours, France.
² Pediatric Pulmonology and cystic fibrosis center, La Timone-Enfants University Hospital, Marseille, France.
³ Cystic Fibrosis Centre, Cochin University Hospital, Paris, France.
⁴ Pediatric Pulmonology and cystic fibrosis center, La Timone-Enfants University Hospital, Marseille, France; Aix-Marseille Univ, IRD, APHM, Mephi, IHU Méditerranée Infection, Marseille, France. Electronic address: [email protected].

PMID: 30904464
DOI: 10.1016/j.jcf.2019.03.004

Abstract

Fifty-two meshes of e-flow rapid® were characterized for tobramycin delivery with a laser diffractometer after 6 months of home use by cystic fibrosis patients treated with various nebulized drugs. Three meshes were out of order and 30 considered to be defective for tobramycin delivery. The use of the specific mesh cleaning shower system permitted 14 defective meshes to be in the expected range of nebulized volume.

Keywords: Cystic fibrosis; In vitro study; Mesh-nebulizer; Tobramycin.

MeSH terms

Administration, Inhalation
Anti-Bacterial Agents / therapeutic use
Cystic Fibrosis / drug therapy*
Equipment Contamination / prevention & control
Equipment Failure Analysis
Equipment Failure*
Humans
Nebulizers and Vaporizers* / microbiology
Nebulizers and Vaporizers* / standards
Pseudomonas Infections / prevention & control*
Self Care / instrumentation
Self Care / methods
Tobramycin / therapeutic use*

Substances

Anti-Bacterial Agents
Tobramycin