Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea

Dae-Hyuk Heo; Joo-Hee Hwang; Seung Hee Choi; Mir Jeon; Ju-Hyung Lee; Jae-Hoon Lee; Seon-Do Hwang; Kyeong-Ah Lee; Seung-Hun Lee; Chang-Seop Lee

doi:10.3346/jkms.2019.34.e87

Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea

J Korean Med Sci. 2019 Mar 12;34(11):e87. doi: 10.3346/jkms.2019.34.e87. eCollection 2019 Mar 25.

Authors

Dae-Hyuk Heo¹, Joo-Hee Hwang^{2

3}, Seung Hee Choi⁴, Mir Jeon², Ju-Hyung Lee⁵, Jae-Hoon Lee⁶, Seon-Do Hwang^{7

8}, Kyeong-Ah Lee⁸, Seung-Hun Lee^{7

9}, Chang-Seop Lee^{2

3}

Affiliations

¹ Department of Internal Medicine, Design Hospital, Jeonju, Korea.
² Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
³ Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
⁴ Department of Industrial Design, Chonbuk National University, Jeonju, Korea.
⁵ Department of Preventive Medicine, Chonbuk National University Medical School, Jeonju, Korea.
⁶ Department of Internal Medicine, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea.
⁷ Division of Zoonoses, Center for Immunology and Pathology, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.
⁸ Division of Bacterial Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, Korea.
⁹ Yeosu National Quarantine Office, Korea Centers for Disease Control and Prevention, Yeosu, Korea.

Abstract

We report 17 patients with human granulocytic anaplasmosis between January 2015 and September 2018 at two tertiary university hospitals in Korea. Monthly incidence peaked in May and June. Among these patients, we identified three who were co-infected with scrub typhus, and one patient with hemorrhagic fever with renal syndrome.

Keywords: Anaplasmosis; Korea; Korean Hemorrhagic Fever; Scrub Typhus.

MeSH terms

Aged
Aged, 80 and over
Anaplasma / immunology
Anaplasmosis / diagnosis*
Anaplasmosis / epidemiology
Anaplasmosis / microbiology
Coinfection / diagnosis
Coinfection / epidemiology
Female
Fluorescent Antibody Technique, Indirect
Hantaan virus / genetics
Hantaan virus / immunology
Hemorrhagic Fever with Renal Syndrome / diagnosis*
Hemorrhagic Fever with Renal Syndrome / epidemiology
Hemorrhagic Fever with Renal Syndrome / virology
Humans
Immunoglobulins / blood
Incidence
Male
Orientia tsutsugamushi / genetics
Orientia tsutsugamushi / immunology
RNA, Viral / genetics
RNA, Viral / metabolism
Republic of Korea / epidemiology
Scrub Typhus / diagnosis*
Scrub Typhus / epidemiology
Scrub Typhus / virology
Seasons

Substances

Immunoglobulins
RNA, Viral