[Impact of glaucoma medications and ocular surface disease on the quality of life of glaucoma patients in the district of Sousse (Tunisia)]

J Fr Ophtalmol. 2019 May;42(5):464-470. doi: 10.1016/j.jfo.2018.06.007. Epub 2019 Mar 28.
[Article in French]

Abstract

Purpose: To assess the impact of glaucoma treatment and ocular surface disease (OSD) on the vision-specific quality-of-life (VS-QoL) of glaucoma patients attending Farhat Hached university hospital Sousse-Tunisia.

Methods: This was a cross-sectional study enrolling one-hundred-twenty patients followed for primary open angle glaucoma. All patients successfully responded to the Arabic version of the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ 25). QoL was quantified in terms of scores (0-100) and correlated with the characteristics of glaucoma treatment and status of the ocular surface.

Results: One hundred and twenty patients were studied. The mean number of medications and instilled drops was 1.95 (1-4) and 2.69 (1-7) respectively. A total of 66.7% patients reported side effects of treatment. On examination, moderate or severe dry eye syndrome was identified in 90% of cases. A total of 16.7% of patients had superficial punctate keratopathy. The number of instilled drops per day, the use of brimonidine or oral carbonic anhydrase inhibitors, and the presence of OSD had a negative impact on the NEI-VFQ 25 scores.

Conclusions: Glaucoma treatment and OSD are 2 factors potentially reducing the QoL of glaucoma patients, on which the ophthalmologist can act by optimizing treatment and regularly examining the ocular surface of glaucoma patients.

Keywords: Glaucoma; Glaucoma treatment; Glaucome; NEI-VFQ; NEI-VFQ 25; Ocular surface disease; Pathologie de surface oculaire; Quality of life; Qualité de vie; Traitement antiglaucomateux.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / adverse effects*
  • Cross-Sectional Studies
  • Dry Eye Syndromes / chemically induced
  • Dry Eye Syndromes / epidemiology*
  • Eye / drug effects
  • Eye / pathology
  • Female
  • Glaucoma, Open-Angle / drug therapy*
  • Glaucoma, Open-Angle / epidemiology*
  • Glaucoma, Open-Angle / pathology
  • Humans
  • Intraocular Pressure / drug effects
  • Keratitis / chemically induced
  • Keratitis / epidemiology*
  • Male
  • Middle Aged
  • Ophthalmic Solutions / administration & dosage
  • Ophthalmic Solutions / adverse effects
  • Quality of Life*
  • Surface Properties / drug effects
  • Surveys and Questionnaires
  • Treatment Outcome
  • Tunisia / epidemiology
  • Vision Disorders / epidemiology
  • Vision Disorders / etiology
  • Visual Fields / drug effects

Substances

  • Antihypertensive Agents
  • Ophthalmic Solutions