Abstract
Microinjection of the dopamine receptor agonist apomorphine, and to a lesser extent dopamine itself, into the nucleus raphe magnus increased tail flick latency in conscious rats. The hypoalgesia was dependent on the integrity of catecholamine-containing pathways originating near the third ventricle and was diminished by systemic depletion of hydroxytryptamine. No simple neuronal circuitry could explain all the effects observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5,6-Dihydroxytryptamine / administration & dosage
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5,6-Dihydroxytryptamine / pharmacology
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Animals
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Apomorphine / administration & dosage
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Apomorphine / pharmacology*
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Cerebral Ventricles / drug effects
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Dopamine / administration & dosage
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Dopamine / pharmacology*
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Hydroxydopamines / administration & dosage
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Hydroxydopamines / pharmacology
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Male
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Microinjections
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Nociceptors / drug effects*
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Oxidopamine
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Periaqueductal Gray / drug effects
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Phenylalanine / administration & dosage
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Phenylalanine / pharmacology
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Raphe Nuclei*
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Rats
Substances
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Hydroxydopamines
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Phenylalanine
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Oxidopamine
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Apomorphine
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Dopamine
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5,6-Dihydroxytryptamine