Isolated cilioretinal artery occlusion secondary to perinuclear antineutrophil cytoplasmic antibody vasculitis

Eur J Ophthalmol. 2020 Sep;30(5):NP53-NP57. doi: 10.1177/1120672119841541. Epub 2019 Apr 5.

Abstract

Introduction: Antineutrophil cytoplasm antibody-associated vasculitides encompass a diverse spectrum of autoimmune diseases characterized by necrotizing small vessel vasculitis. Ocular manifestations may be the presenting findings of antineutrophil cytoplasm antibody-associated vasculitides.

Methods: Single, retrospective case study.

Results: We report the rare case of a 55-year-old woman with a cilioretinal artery occlusion as the presenting feature of perinuclear antineutrophil cytoplasm antibody-associated microscopic polyangiitis.

Conclusions: Although rare, antineutrophil cytoplasm antibody-related vasculitis should be considered in any retinal vascular occlusion, particularly in the setting of patients with new vague headaches and a paucity of vasculopathic risk factors.

Keywords: Cilioretinal artery occlusion; antineutrophil cytoplasm antibody; microscopic polyangiitis; vasculitis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / complications*
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Arterial Occlusive Diseases / diagnosis
  • Arterial Occlusive Diseases / etiology*
  • Blood Sedimentation
  • C-Reactive Protein / metabolism
  • Ciliary Arteries / pathology*
  • Female
  • Fluorescein Angiography
  • Humans
  • Middle Aged
  • Peroxidase / immunology
  • Retinal Artery / pathology*
  • Retrospective Studies

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • C-Reactive Protein
  • MPO protein, human
  • Peroxidase