Chromosomes are not very mobile during interphase. In this issue, Nagashima et al. (2019. J. Cell Biol https://doi.org/10.1083/jcb.201811090) propose that the overall stabilization of genome structure is achieved by loose connections between DNA regions brought about by transcriptionally active RNA polymerases.
© 2019 Hochberg-Laufer and Shav-Tal.