Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study

Open Forum Infect Dis. 2019 Feb 26;6(3):ofz068. doi: 10.1093/ofid/ofz068. eCollection 2019 Mar.

Abstract

The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.

Keywords: Ebola virus; clinical sequelae; immune responses; virus genome; virus persistence.