Travel-related health events and their risk factors in HIV-infected sub-Saharan migrants living in France and visiting their native country: The ANRS VIHVO cohort study

Travel Med Infect Dis. 2019 May-Jun:29:40-47. doi: 10.1016/j.tmaid.2019.03.010. Epub 2019 Apr 2.

Abstract

Background: Literature on health events in HIV-infected travellers is scarce, particularly in sub-Saharan African (SSA) migrants.

Methods: We investigated health events in HIV-infected SSA migrants living in France during and after travel to their native country. All had a pre-travel plasma viral load (pVL) below 200 copies/mL and were on stable combined antiretroviral therapy (cART). Logistic regression models were used to assess the risk factors for at least one adverse health event or febrile event.

Results: Among 264 HIV migrants, pre-travel median CD4 count was 439/mm3 and 27 migrants (6%) experienced a low-level viremia between 50 and 200 copies/mL. One hundred (38%) experienced at least one event (13 experienced two events). The most common events were gastrointestinal, including diarrhoea (n = 29, 26%), respiratory events (n = 20, 18%), and malaria (n = 17, 15%; 1 death). In multivariable analysis, a pre-travel low-level viremia and a lack of pre-travel medical advice significantly increased the risk for any event (OR 4.31, 95% CI, 1.41-13.1; and OR 3.62, 95% CI, 1.38-9.47; respectively). A lack of pre-travel advice significantly increased the risk for febrile event.

Conclusions: Early and tailored counselling on pre-travel medical advice regarding diarrhoea and vector-borne diseases prophylactic measures in HIV-infected SSA migrants should be emphasised before travel to Africa.

Keywords: HIV infection; Health event; Migrant; Sub-Saharan Africa; Travel; Visiting friends and relatives.

MeSH terms

  • Africa South of the Sahara / ethnology
  • Anti-Retroviral Agents / therapeutic use
  • Fever / epidemiology
  • France / epidemiology
  • Gastrointestinal Diseases / epidemiology
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • Humans
  • Malaria / epidemiology
  • Malaria / mortality
  • Respiratory Tract Diseases / epidemiology
  • Risk Factors
  • Transients and Migrants / statistics & numerical data*
  • Travel-Related Illness*
  • Viral Load

Substances

  • Anti-Retroviral Agents