Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

Sara Mariotto; Sergio Ferrari; Matteo Gastaldi; Diego Franciotta; Elia Sechi; Ruggero Capra; Chiara Mancinelli; Kathrin Schanda; Daniela Alberti; Riccardo Orlandi; Roberto Bombardi; Luigi Zuliani; Marco Zoccarato; Maria Donata Benedetti; Raffaella Tanel; Francesca Calabria; Francesca Rossi; Antonino Pavone; Luisa Grazian; GianPietro Sechi; Lucia Batzu; Noemi Murdeu; Francesco Janes; Vincenza Fetoni; Daniela Fulitano; Gianola Stenta; Lisa Federle; Gaetano Cantalupo; Markus Reindl; Salvatore Monaco; Alberto Gajofatto

doi:10.1136/jnnp-2018-320287

Neurofilament light chain serum levels reflect disease severity in MOG-Ab associated disorders

J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1293-1296. doi: 10.1136/jnnp-2018-320287. Epub 2019 Apr 5.

Authors

Sara Mariotto¹, Sergio Ferrari², Matteo Gastaldi³, Diego Franciotta³, Elia Sechi⁴, Ruggero Capra⁵, Chiara Mancinelli⁵, Kathrin Schanda⁶, Daniela Alberti², Riccardo Orlandi², Roberto Bombardi⁷, Luigi Zuliani⁸, Marco Zoccarato⁹, Maria Donata Benedetti², Raffaella Tanel¹⁰, Francesca Calabria¹¹, Francesca Rossi¹², Antonino Pavone¹³, Luisa Grazian¹⁴, GianPietro Sechi¹⁵, Lucia Batzu⁴, Noemi Murdeu⁴, Francesco Janes¹⁶, Vincenza Fetoni¹⁷, Daniela Fulitano¹⁸, Gianola Stenta¹⁹, Lisa Federle¹⁹, Gaetano Cantalupo²⁰, Markus Reindl⁶, Salvatore Monaco², Alberto Gajofatto²

Affiliations

¹ Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy [email protected].
² Department of Neuroscience, Biomedicine, and Movement Sciences, Section of Neurology, University of Verona, Verona, Italy.
³ Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy, Pavia, Italy.
⁴ Department of Clinical and Experimental Medicine, Neurology Unit, University of Sassari, Sassari, Italy.
⁵ MS Center, Spedali Civili of Brescia, Brescia, Italy.
⁶ Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
⁷ Neurology Unit, San Bassiano Hospital, Bassano Del Grappa, Italy.
⁸ Department of Neurology, Ospedale Ca' Foncello, Treviso, Italy.
⁹ O.S.A, Padova, Italy, Neurology Unit, Padova, Italy.
¹⁰ U.O. Neurologia, S. Chiara Hospital, Trento, Italy.
¹¹ AOUI Verona, Neurology Unit, Verona, Italy.
¹² Neurology Unit, Mater Salutis Hospital, Legnago, Verona, Italy, Verona, Italy.
¹³ Neurology Unit, Garibaldi Hospital, Catania, Italy, Catania, Italy.
¹⁴ Pediatric Unit, ULSS 2 Marca Trevigiana, Ca' Foncello Hospital, Treviso, Italy, Treviso, Italy.
¹⁵ Department of Clinical and Experimental Medicine, NeurologyUnit, University of Sassari, Sassari, Italy.
¹⁶ Neurology Unit, Department of Neuroscience ASUIUD, Udine, Italy, Udine, Italy.
¹⁷ Neurology Department, ASST Fatebenefratelli Sacco, Milano, Italy, Milano, Italy.
¹⁸ Neurology Unit, Rovigo, Italy, Rovigo, Italy.
¹⁹ Multiple Sclerosis Centre, S. Bortolo Hospital, Vicenza, Italy, Vicenza, Italy.
²⁰ Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.

PMID: 30952681
DOI: 10.1136/jnnp-2018-320287

No abstract available

Keywords: MOG; NMOSD; myelitis; neurofilament light chain; optic neuritis.

Publication types

Letter

MeSH terms

Adolescent
Adult
Age Factors
Aged
Antibodies / blood
Biomarkers / blood
Biomarkers / cerebrospinal fluid
Case-Control Studies
Child
Demyelinating Diseases / blood*
Demyelinating Diseases / cerebrospinal fluid
Demyelinating Diseases / diagnosis*
Demyelinating Diseases / immunology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / blood*
Multiple Sclerosis / cerebrospinal fluid
Multiple Sclerosis / diagnosis*
Multiple Sclerosis / immunology
Myelin-Oligodendrocyte Glycoprotein / immunology*
Neurofilament Proteins / blood*
Neurofilament Proteins / cerebrospinal fluid
Neuroimaging
Young Adult

Substances

Antibodies
Biomarkers
Myelin-Oligodendrocyte Glycoprotein
Neurofilament Proteins
neurofilament protein L