Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity

Andrew Baessler; J Scott Hale

doi:10.1016/j.it.2019.03.007

Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity

Trends Immunol. 2019 May;40(5):377-379. doi: 10.1016/j.it.2019.03.007. Epub 2019 Apr 4.

Authors

Andrew Baessler¹, J Scott Hale²

Affiliations

¹ Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
² Department of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: [email protected].

Abstract

Group A Streptococcus (GAS) infection causes recurrent tonsillitis (RT) in some individuals. A recent study (Dan et al. Sci. Transl. Med. 2019;11:eaau3776) demonstrates that RT is associated with an impaired antibody response against a key streptococcal virulence factor. This factor, SpeA, can induce abnormal T follicular helper (Tfh) cells that are able to kill B cells.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

B-Lymphocytes
Humans
Streptococcus
T-Lymphocytes, Helper-Inducer*
Tonsillitis*

Abstract

Publication types

MeSH terms

Grants and funding