A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

Deqin Cai; Yanli Yao; Yubo Tang; Zheng Wang; Wei Shi; Wei Huang; Kan Ding

doi:10.3390/polym9100536

A Concise Synthesis of Three Branches Derived from Polysaccharide RN1 and Anti-Pancreatic Cancer Activity Study

Polymers (Basel). 2017 Oct 21;9(10):536. doi: 10.3390/polym9100536.

Authors

Deqin Cai^{1

2}, Yanli Yao^{3

4}, Yubo Tang^{5

6}, Zheng Wang^{7

8}, Wei Shi^{9

10}, Wei Huang^{11

12}, Kan Ding^{13

14}

Affiliations

¹ University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. [email protected].
² Glycochemistry and Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. [email protected].
³ University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. [email protected].
⁴ Glycochemistry and Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. [email protected].
⁵ CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, China. [email protected].
⁶ Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. [email protected].
⁷ Glycochemistry and Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. [email protected].
⁸ Nano Science and Technology Institute, University of Science and Technology of China, 96 Jin Zhai Road, Hefei 230026, China. [email protected].
⁹ University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. [email protected].
¹⁰ CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, China. [email protected].
¹¹ University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. [email protected].
¹² CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, China. [email protected].
¹³ University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. [email protected].
¹⁴ Glycochemistry and Glycobiology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. [email protected].

Abstract

RN1, a polysaccharide from flowers of Panax pseudo-ginsieng Wall. Var. notoginseng (Burkill) Hoo & Tseng, is a potential multi-targeting drug candidate for pancreatic cancer treatment. However, the active targeting domain of RN1 is still unknown. Herein, three RN1 derived branches were synthesized via [3+2] or [2+2] strategies, efficiently. Two pentasaccharides, 18 and 27, showed similar inhibition effect on pancreatic cancer BxPC-3 cells to that of RN1 at same concentration. Interestingly, tetrasaccharide 21 potently inhibited gemcitabineresistant cell line Panc-1 at high concentration. These suggest that the branches of RN1 might be the active targeting domain and tetrasaccharide 21 might be a potential leading compound for pancreatic cancer with gemcitabine resistance.

Keywords: arabinogalactan; carbohydrate chemistry; gemcitabine resistance; pancreatic cancer.

Abstract

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