Production of a trioxacarcin analog by introducing a C-3 dehydratase into deoxysugar biosynthesis

Acta Biochim Biophys Sin (Shanghai). 2019 May 23;51(5):539-541. doi: 10.1093/abbs/gmz024.

Authors

Yi Shen¹, Qiu-Yue Nie², Yue Yin², Hai-Xue Pan², Bin Xu¹, Gong-Li Tang²

Affiliations

¹ Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.
² State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

PMID: 30968938
DOI: 10.1093/abbs/gmz024

No abstract available

MeSH terms

Aminoglycosides / biosynthesis*
Aminoglycosides / chemistry
Aminoglycosides / pharmacology
Anthracyclines / chemistry
Anthracyclines / metabolism
Anthracyclines / pharmacology
Carbonic Anhydrases / metabolism*
Cell Survival / drug effects
Humans
Inhibitory Concentration 50
Jurkat Cells
Models, Chemical
Molecular Structure
Streptomyces / metabolism*

Substances

Aminoglycosides
Anthracyclines
kosinostatin
trioxacarcin
Carbonic Anhydrases