Leiomyosarcoma: Clinicopathological study and retrospective analysis of prognostic factors in a series of 100 patients

Francesco Muratori; Daniela Greto; Mauro Cenatiempo; Giacomo Mazzei; Filippo Frenos; Giuliana Roselli; Lorenzo Livi; Rodolfo Capanna; Giacomo Baldi; Domenico Andrea Campanacci

doi:10.1016/j.jor.2019.03.004

Leiomyosarcoma: Clinicopathological study and retrospective analysis of prognostic factors in a series of 100 patients

J Orthop. 2019 Mar 25;16(4):303-307. doi: 10.1016/j.jor.2019.03.004. eCollection 2019 Jul-Aug.

Affiliations

¹ Divisione di Ortopedia Oncologica e Ricostruttiva Azienda Ospedaliero Universitaria Careggi Firenze, Italy.
² Unità di Radioterapia Azienda Ospedaliero Universitaria Careggi Firenze, Italy.
³ Divisione di Radiologia Azienda Ospedaliero Universitaria Careggi Firenze, Italy.
⁴ Divisione Oncologia Ospedale Prato, Italy.

Abstract

The Authors reported a retrospective study of 100 Leiomyosarcoma (LMS), evaluating factors that may influence Overall Survival (OS), Local Recurrence Free Survival (LRFS), Metastasis Free Survival (MFS). Tumor Size (P = 0,0009), Local Recurrence (P = 0,0487), Distant relapse (P < 0,0001), Type of Presentation (P = 0,0213) were significant risk factors affecting overall survival (OS). Tumor Size (P = 0.024), age at diagnosis (P = 0,0086), type of presentation (P < 0,0001) and Local Recurrence (P = 0.0152) affected metastasis free survival (MFS). Type of presentation (P = 0,001) was an independent prognostic factor of local recurrence-free survival (LRFS).

Keywords: Age; Leiomyosarcoma; Metastasis; Recurrence; Size.