Emergence of plasmid-encoded VIM-2-producing Pseudomonas aeruginosa isolated from clinical samples in Lebanon

T Nawfal Dagher; C Al-Bayssari; S M Diene; E Azar; J-M Rolain

doi:10.1016/j.nmni.2019.100521

Emergence of plasmid-encoded VIM-2-producing Pseudomonas aeruginosa isolated from clinical samples in Lebanon

New Microbes New Infect. 2019 Feb 22:29:100521. doi: 10.1016/j.nmni.2019.100521. eCollection 2019 May.

Authors

T Nawfal Dagher^{1

2}, C Al-Bayssari³, S M Diene¹, E Azar², J-M Rolain¹

Affiliations

¹ Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385 Marseille, Cedex 05 France.
² Saint George Hospital University Medical Center, Faculty of Medicine and Medical Sciences, University of Balamand, Beirut, Lebanon.
³ Faculty of Sciences III, Lebanese University, Tripoli, Lebanon.

Abstract

The present study aimed to describe the emergence of carbapenem-resistant Pseudomonas aeruginosa isolated from clinical Lebanese patients. The resistance of these isolates is due to the presence of the plasmid-encoded bla _VIM-2 gene. We provide its first description in Lebanon, as well as a description of disruption of the oprD gene by mutations.

Keywords: Carbapenem resistance; Pseudomonas aeruginosa; VIM-2; oprDgene.