Diagnostic testing for male infertility has traditionally been limited to andrology labs. The advent of home-based semen testing has the potential to allow patients to perform testing in the comfort of their home and screen those who need a formal evaluation. An extensive review of the literature was performed. There are several FDA-approved devices for home semen testing. The mechanism of the test and the results provided differ by test. The existing tests are limited in their diagnostic capabilities but may fill a niche for men who do not have access to andrology lab testing or prefer home testing.