Chandelier Cells Swipe Right for L1CAM

Ryan Hamnett; Julia A Kaltschmidt

doi:10.1016/j.neuron.2019.03.038

Chandelier Cells Swipe Right for L1CAM

Neuron. 2019 Apr 17;102(2):267-270. doi: 10.1016/j.neuron.2019.03.038.

Authors

Ryan Hamnett¹, Julia A Kaltschmidt²

Affiliations

¹ Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

PMID: 30998894
DOI: 10.1016/j.neuron.2019.03.038

Abstract

Establishing a functional neuronal circuit requires not only synapsing with the right cell type, but also targeting the right subcellular compartment. In this issue of Neuron, Tai et al. (2019) identify the cell adhesion molecule L1CAM as integral to the mechanism by which chandelier cells establish subcellular compartment-specific innervation of pyramidal neurons in the mammalian cerebral cortex.

Keywords: L1CAM; axon initial segment; cell adhesion molecule; chandelier cells; pyramidal neurons; subcellular specificity.

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MeSH terms

Animals
Axons
Neocortex*
Neural Cell Adhesion Molecule L1*
Neurons
Pyramidal Cells

Substances

Neural Cell Adhesion Molecule L1