RETRACTED: A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p

Biochem Biophys Res Commun. 2019 Jun 11;513(4):812-819. doi: 10.1016/j.bbrc.2019.03.214. Epub 2019 Apr 16.

Abstract

This article has been retracted at the request of the authors: please see Elsevier policy on article withdrawal (https://www.elsevier.com/locate/withdrawalpolicy). The authors claim that other members of their lab attempted to repeat the experiments in this study several times and found that the activation ability of snail on circ-znf652 was significantly lower than reported, indicating that this regulation loop does not exist. The authors' incorrect experimental method and lack of reasonable control, coupled with the lack of experimental experience of the first author, led to the mistakes and mean the results cannot be relied upon. In order not to mislead other scientists, they requested to retract their manuscript. The Editor-in-Chief has approved this retraction. The authors apologise to the readership of the journal for these errors.

Keywords: Circular RNA; Epithelial-mesenchymal transition; Hepatocellular carcinoma; Metastasis; microRNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Base Sequence
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology*
  • Cell Line, Tumor
  • Epithelial-Mesenchymal Transition / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology*
  • Male
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • Promoter Regions, Genetic / genetics
  • Protein Binding / genetics
  • RNA, Circular
  • Snail Family Transcription Factors / metabolism*
  • Up-Regulation / genetics

Substances

  • MIRN203 microRNA, human
  • MIRN502 microRNA, human
  • MicroRNAs
  • RNA, Circular
  • Snail Family Transcription Factors