CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs

Blood. 2019 Jun 6;133(23):2542-2545. doi: 10.1182/blood.2019000800. Epub 2019 Apr 19.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CRISPR-Cas Systems
  • Disease Models, Animal*
  • Gene Editing / methods
  • Hematopoietic Stem Cells*
  • Hemoglobinuria, Paroxysmal / genetics*
  • Macaca mulatta
  • Membrane Proteins / genetics*

Substances

  • Membrane Proteins
  • phosphatidylinositol glycan-class A protein