Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33

Allergy. 2019 Nov;74(11):2237-2240. doi: 10.1111/all.13831. Epub 2019 Jul 15.

Authors

Natsuko Maruyama^{1

2}, Toshiro Takai¹, Seiji Kamijo¹, Punyada Suchiva^{1

2}, Mai Ohba³, Tomohito Takeshige⁴, Mayu Suzuki¹, Mutsuko Hara¹, Kei Matsuno⁴, Sonoko Harada⁴, Norihiro Harada⁴, Susumu Nakae⁵, Katsuko Sudo⁶, Toshiaki Okuno³, Takehiko Yokomizo³, Hideoki Ogawa², Ko Okumura¹, Shigaku Ikeda^{1

2}

Affiliations

¹ Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
² Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
³ Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁴ Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁵ Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁶ Pre-clinical Research Center, Tokyo Medical University, Tokyo, Japan.

PMID: 31006115
DOI: 10.1111/all.13831

No abstract available

Keywords: IL-33; asthma; murine models; nonsteroidal anti-inflammatory drug; protease allergen.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity / drug effects*
Allergens / immunology*
Animals
Asthma / drug therapy
Asthma / immunology
Asthma / metabolism
Asthma / pathology
Cyclooxygenase Inhibitors / pharmacology*
Cytokines / metabolism
Disease Models, Animal
Immunity, Innate / drug effects*
Interleukin-13 / immunology*
Mice
Peptide Hydrolases / immunology*
Prostaglandin-Endoperoxide Synthases / metabolism*
T-Lymphocyte Subsets / drug effects
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism

Substances

Allergens
Cyclooxygenase Inhibitors
Cytokines
Interleukin-13
Prostaglandin-Endoperoxide Synthases
Peptide Hydrolases

Grants and funding