Myeloid malignancies-related somatic mutations in aging individuals

Diego F Coutinho; Ilana R Zalcberg; Bárbara C R Monte-Mór

doi:10.1002/mgg3.683

Myeloid malignancies-related somatic mutations in aging individuals

Mol Genet Genomic Med. 2019 Jun;7(6):e683. doi: 10.1002/mgg3.683. Epub 2019 Apr 21.

Authors

Diego F Coutinho^{1

2}, Ilana R Zalcberg¹, Bárbara C R Monte-Mór¹

Affiliations

¹ Laboratório de Biologia Molecular, Centro de Transplante de Medula Óssea, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
² Perlmutter Cancer Center, New York University Langone Health, New York, New York.

Abstract

We search for the presence of somatic mutations in 12 genes related to MDS, MPN, and AML in a Brazilian cohort composed of 609 elderly individuals from a census-based sample.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Aged
Aged, 80 and over
Brazil / epidemiology
Cohort Studies
Exome Sequencing / methods
Female
Hematopoiesis
Humans
Leukemia, Myeloid / blood
Leukemia, Myeloid / epidemiology
Leukemia, Myeloid / genetics*
Male
Middle Aged
Mutation
Neoplasms / blood
Neoplasms / epidemiology
Neoplasms / genetics*