Benign Gastric Ulcer with Epstein-Barr Virus Infection Mimicking Malignant Gastric Ulcer

Korean J Gastroenterol. 2019 Mar 25;73(3):177-181. doi: 10.4166/kjg.2019.73.3.177.

Abstract

Epstein-Barr virus (EBV) is the cause of infectious mononucleosis, which is characterized by fever, lymphadenopathy, and sore throat. On the other hand, gastrointestinal symptoms of EBV infection like dyspepsia, abdominal pain are non-specific and rarely encountered, which means it is difficult to diagnose gastric involvement of EBV infection without suspicion. The relation between gastric carcinoma and gastric lymphoma associated with EBV infection is well defined, but relations with other EBV-associated gastrointestinal diseases such as gastritis and peptic ulcer disease have rarely been reported. We report a case of benign gastric ulcer with EBV infection confirmed by endoscopic and histological findings.

Keywords: Epstein-Barr virus infections; Helicobacter pylori; In situ hybridization; Peptic ulcer; Stomach ulcer.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Capsid Proteins / immunology
  • DNA, Viral / metabolism
  • Diagnosis, Differential
  • Endoscopy, Digestive System
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / diagnosis*
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification
  • Herpesvirus 4, Human / metabolism
  • Humans
  • Male
  • Stomach Ulcer / complications
  • Stomach Ulcer / diagnosis*
  • Stomach Ulcer / pathology

Substances

  • Antibodies, Viral
  • Capsid Proteins
  • DNA, Viral