7TM proteins are not necessarily GPCRs

Mol Cell Endocrinol. 2019 Jul 1:491:110397. doi: 10.1016/j.mce.2019.02.009. Epub 2019 Apr 24.

Abstract

In this review article, we summarize the current knowledge on a large and diverse superfamily of seven-pass transmembrane proteins functionally independent from the GPCR superfamily. We include the newest research findings about their physiological roles and their mechanism of action. In particular, we concentrate on the structural basis for the newly discovered amide hydrolase activity, with a focus on adiponectin receptors for which structures are available. Finally, we discuss the remaining challenges in understanding the activation and signaling of these intramembrane proteins and suggest how regulation of the amide hydrolase activity may help in development of new therapeutic agents.

Keywords: 7TM; ADIPOR; Adiponectin receptors; Amidase; Hydrolase; Intramembrane ceramidases; Structural biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amidohydrolases / chemistry
  • Amidohydrolases / metabolism*
  • Amino Acid Sequence
  • Animals
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Receptors, Adiponectin / chemistry
  • Receptors, Adiponectin / metabolism*
  • Receptors, G-Protein-Coupled / chemistry
  • Receptors, G-Protein-Coupled / metabolism*
  • Sequence Homology

Substances

  • Membrane Proteins
  • Receptors, Adiponectin
  • Receptors, G-Protein-Coupled
  • Amidohydrolases