The Role of ARID1A in Endometrial Cancer and the Molecular Pathways Associated With Pathogenesis and Cancer Progression

In Vivo. 2019 May-Jun;33(3):659-667. doi: 10.21873/invivo.11524.

Abstract

AT-rich interaction domain 1A gene (ARID1A) encodes for a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, a chromatin remodeling complex, and it has been implicated in the pathogenesis of various cancer types. In this review, we discuss how ARID1A is linked to endometrial cancer and what molecular pathways are affected by mutation or inhibition of ARID1A. We also discuss the potential use of ARID1A not only as a prognostic biomarker, but also as a target for therapeutic interventions.

Keywords: ARID1A; endometrial cancer; molecular pathways; review.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins
  • Disease Progression
  • Disease Susceptibility
  • Endometrial Neoplasms / etiology*
  • Endometrial Neoplasms / metabolism*
  • Endometrial Neoplasms / pathology
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Mutation
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism*
  • Signal Transduction*
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*

Substances

  • ARID1A protein, human
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Transcription Factors