A20: A multifunctional tool for regulating immunity and preventing disease

Cell Immunol. 2019 Jun:340:103914. doi: 10.1016/j.cellimm.2019.04.002. Epub 2019 Apr 5.

Abstract

A20, also known as TNFAIP3, is a potent regulator of ubiquitin (Ub) dependent signals. A20 prevents multiple human diseases, indicating that the critical functions of this protein are clinically as well as biologically impactful. As revealed by mouse models, cell specific functions of A20 are linked to its ability to regulate diverse signaling pathways. Aberrant expression or functions of A20 in specific cell types underlie divergent disease outcomes. Discernment of A20's biochemical functions and their phenotypic outcomes will contribute to our understanding of how ubiquitination is regulated, how Ub mediated functions can prevent disease, and will pave the way for future therapeutic interventions.

Keywords: A20; Autoimmunity; Inflammation; Innate immunity; TNFAIP3; Ubiquitin.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / pathology
  • Arthritis, Rheumatoid / prevention & control
  • Asthma / genetics
  • Asthma / immunology*
  • Asthma / pathology
  • Asthma / prevention & control
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology
  • B-Lymphocytes / pathology
  • Disease Models, Animal
  • Humans
  • Immunity, Innate / drug effects
  • Immunologic Factors / therapeutic use
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / pathology
  • Lupus Erythematosus, Systemic / prevention & control
  • Molecular Targeted Therapy / methods
  • NF-kappa B / genetics
  • NF-kappa B / immunology
  • Protein Processing, Post-Translational*
  • Signal Transduction
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology
  • Tumor Necrosis Factor alpha-Induced Protein 3 / genetics*
  • Tumor Necrosis Factor alpha-Induced Protein 3 / immunology
  • Ubiquitination

Substances

  • Immunologic Factors
  • NF-kappa B
  • TNFAIP3 protein, human
  • Tumor Necrosis Factor alpha-Induced Protein 3