Pathogenic Germ Line Variants in a Patient With Severe Toxicity From Breast Radiotherapy

Clin Breast Cancer. 2019 Jun;19(3):e400-e405. doi: 10.1016/j.clbc.2019.03.004. Epub 2019 Mar 28.
No abstract available

Keywords: Cardiac toxicity; DNA repair; DNA replication; Fibrosis; Genetic alterations; Radiosensitivity.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / radiotherapy*
  • Carcinoma, Ductal, Breast / genetics
  • Carcinoma, Ductal, Breast / pathology
  • Carcinoma, Ductal, Breast / radiotherapy
  • DNA Repair / genetics*
  • DNA Repair Enzymes / genetics*
  • Exome Sequencing
  • Female
  • Germ-Line Mutation*
  • Humans
  • Middle Aged
  • Prognosis
  • Radiation Injuries / etiology*
  • Radiation Injuries / pathology
  • Radiotherapy / adverse effects*

Substances

  • DNA Repair Enzymes