Abstract
Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in a patient with trisomy 21. Here we report the case of a 14-year-old girl with trisomy 21 with impaired control of EBV and DLBCL. She was cured with dose-adapted chemotherapy and hematopoietic stem cell transplantation without severe treatment-related toxicity. We describe the first case of EBV-positive DLBCL in a patient with trisomy 21 and we propose a treatment modality for this rare entity.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Combined Modality Therapy
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Down Syndrome / complications
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Down Syndrome / genetics
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Down Syndrome / therapy*
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Down Syndrome / virology
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / therapy*
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Epstein-Barr Virus Infections / virology
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Female
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Hematopoietic Stem Cell Transplantation / methods*
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Herpesvirus 4, Human / isolation & purification*
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Humans
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Lymphoma, Large B-Cell, Diffuse / complications
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Lymphoma, Large B-Cell, Diffuse / genetics
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Lymphoma, Large B-Cell, Diffuse / therapy*
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Lymphoma, Large B-Cell, Diffuse / virology
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Prognosis